Fellaini has not started a fixture for United since November, but gets an opportunity to impress at Old Trafford in place of Scott McTominay.
Paul Pogba returns to the squad after a minor injury, but the club's record signing must do with a place among the replacements.
Manchester United: De Gea; Valencia, Bailly, Smalling, Young; Matic, Fellaini; Lingard, Sanchez, Rashford; Lukaku
Subs: Romero, Darmian, Lindelof, McTominay, Mata, Pogba, Martial
Sevilla: Rico; Mercado, Kjaer, Lenglet, Escudero; N'Zonzi, Banega, Sarabia, Vazquez, Correa; Muriel
Subs: Ben Yedder, Geis, Soria, Pizarro, Pareja, Nolito, Lopes
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